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PDE2A
Description
phosphodiesterase 2A
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Presynaptic Membrane
Perinuclear Region Of Cytoplasm
Synaptic Membrane
Molecular Function
Magnesium Ion Binding
3',5'-cyclic-nucleotide Phosphodiesterase Activity
3',5'-cyclic-AMP Phosphodiesterase Activity
CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity
Protein Binding
Zinc Ion Binding
CAMP Binding
CGMP Binding
TPR Domain Binding
Phosphate Ion Binding
Protein Homodimerization Activity
3',5'-cyclic-GMP Phosphodiesterase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Heart Valve Development
Ventricular Septum Development
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Regulation Of CGMP-mediated Signaling
Negative Regulation Of CGMP-mediated Signaling
Regulation Of Mitochondrion Organization
CAMP-mediated Signaling
CGMP-mediated Signaling
Aorta Development
Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Negative Regulation Of Vascular Permeability
Positive Regulation Of Vascular Permeability
Regulation Of CAMP-mediated Signaling
Negative Regulation Of CAMP-mediated Signaling
CGMP Catabolic Process
Positive Regulation Of Inflammatory Response
Establishment Of Endothelial Barrier
Cellular Response To Mechanical Stimulus
Cellular Response To CAMP
Cellular Response To CGMP
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways
cGMP effects
G alpha (s) signalling events
Drugs
Caffeine
Cyclic GMP
ND7001
ND7001
Exisulind
3-isobutyl-1-methyl-7H-xanthine
Tofisopam
Doxofylline
Trapidil
Diseases
GWAS
Household income (MTAG) (
31844048
)
Optic nerve measurement (cup area) (
20395239
)
Rheumatoid arthritis (
22446963
)
Novel Interacting Genes
12 novel interacting genes:
ANAPC15
CHEK1
FAM168A
FCHSD2
FOLR1
GLS2
HSD17B6
LRP5
NDUFV1
RPS3
RPS6KA4
SPAG7
Interacting Genes
Entrez ID
5138
HPRD ID
04041
Ensembl ID
ENSG00000186642
Uniprot IDs
O00408
Q8IW54
PDB IDs
1Z1L
3IBJ
3ITM
3ITU
4C1I
4D08
4D09
4HTX
4HTZ
4JIB
5TZ3
5TZA
5TZC
5TZH
5TZW
5TZX
5TZZ
5U00
5U7D
5U7I
5U7J
5U7K
5U7L
5VP0
5VP1
5XKM
6B96
6B97
6B98
6BLF
6C7D
6C7E
6C7F
6C7G
6C7I
6C7J
6CYB
6CYC
6CYD
6ZND
6ZQZ
Enriched GO Terms of Interacting Partners
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