PCK1

Description		phosphoenolpyruvate carboxykinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding GDP Binding Manganese Ion Binding Carboxylic Acid Binding Protein Serine Kinase Activity (using GTP As Donor)
	Biological Process	Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Aging Response To Activity Peptidyl-serine Phosphorylation Propionate Catabolic Process Response To Lipopolysaccharide Response To Insulin Cellular Response To Insulin Stimulus Response To Lipid Glucose Homeostasis Response To Starvation Positive Regulation Of Memory T Cell Differentiation Glycerol Biosynthetic Process From Pyruvate Regulation Of Lipid Biosynthetic Process Cellular Response To Potassium Ion Starvation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Acidic PH Hepatocyte Differentiation Response To Interleukin-6 Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Response To Methionine
Pathways		Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs		Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 5'-Guanylylmethylenebisphosphonate
Diseases
GWAS		Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prudent dietary pattern ( 28644415) Red blood cell count ( 32888494) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)
Novel Interacting Genes		1 novel interacting genes: RAE1
Interacting Genes		5 interacting genes: APP C1R FBXO25 IKBKG UBR5
Entrez ID		5105
HPRD ID		02028
Ensembl ID		ENSG00000124253
Uniprot IDs		P35558
PDB IDs		1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
Enriched GO Terms of Interacting Partners?
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