INPP5B

Description		inositol polyphosphate-5-phosphatase B
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GO Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Metal Ion Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity
	Biological Process	In Utero Embryonic Development Signal Transduction Spermatogenesis Flagellated Sperm Motility Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Protein Processing
Pathways		Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Rho GTPase cycle
Drugs		D-Myo-Inositol-1,4-Bisphosphate
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autoimmune thyroid disease ( 32581359) Blood protein levels ( 30072576) Eyebrow thickness ( 26926045) Height ( 31562340) Medication use (thyroid preparations) ( 31015401) Pulse pressure ( 28739976) Red cell distribution width ( 27863252) Rheumatoid arthritis ( 30423114 24390342)
Novel Interacting Genes		1 novel interacting genes: PTPRF
Interacting Genes		2 interacting genes: APP SMURF1
Entrez ID		3633
HPRD ID		00924
Ensembl ID		ENSG00000204084
Uniprot IDs		B3KMW4 P32019
PDB IDs		3MTC 3N9V 4CML 5A7I 5A7J
Enriched GO Terms of Interacting Partners?
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