KSR2

Description		kinase suppressor of ras 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Ras Protein Signal Transduction Calcium-mediated Signaling Positive Regulation Of Cold-induced Thermogenesis
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Body mass index ( 29273807) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Body size at age 10 ( 32376654) Coronary artery disease ( 26343387) Depression ( 27089181) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Endometriosis ( 23472165) Hip circumference adjusted for BMI ( 28552196) Late-onset Alzheimer's disease ( 27770636) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Refractive error ( 32231278) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Type 2 diabetes ( 30297969 32499647 30718926) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		5 interacting genes: CYSRT1 MAP2K1 MAPK1 MAPK3 RAF1
Entrez ID		283455
HPRD ID		13952
Ensembl ID		ENSG00000171435
Uniprot IDs		E9PB13 Q6VAB6
PDB IDs		2Y4I 5KKR 7JUQ 7JUR 7JUS 7JUT 7JUU 7JUV
Enriched GO Terms of Interacting Partners?
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