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EIF2AK1
Description
eukaryotic translation initiation factor 2 alpha kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Molecular Function
Protein Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Protein Binding
ATP Binding
Heme Binding
Protein Homodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Acute Inflammatory Response
Phagocytosis
Negative Regulation Of Cell Population Proliferation
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Regulation Of EIF2 Alpha Phosphorylation By Heme
Macrophage Differentiation
Negative Regulation Of Translational Initiation By Iron
Protoporphyrinogen IX Metabolic Process
Protein Autophosphorylation
Negative Regulation Of Hemoglobin Biosynthetic Process
Iron Ion Homeostasis
Integrated Stress Response Signaling
HRI-mediated Signaling
Response To Iron Ion Starvation
Pathways
Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Fostamatinib
Diseases
GWAS
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Novel Interacting Genes
1 novel interacting genes:
SELENOS
Interacting Genes
4 interacting genes:
CDC37
EIF2S1
HSP90AA1
LIG4
Entrez ID
27102
HPRD ID
10684
Ensembl ID
ENSG00000086232
Uniprot IDs
A0A024QZU1
Q9BQI3
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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