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SARM1

Description sterile alpha and TIR motif containing 1
Image
GO Annotations Cellular Component
  • Cytoplasm
  • Mitochondrion
  • Cytosol
  • Microtubule
  • Axon
  • Dendrite
  • Extrinsic Component Of Mitochondrial Outer Membrane
  • Synapse
Molecular Function
  • NAD+ Nucleosidase Activity
  • Protein Binding
  • Signaling Adaptor Activity
  • NAD(P)+ Nucleosidase Activity
  • NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Biological Process
  • Signal Transduction
  • Nervous System Development
  • Response To Glucose
  • NAD Catabolic Process
  • Cell Differentiation
  • Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
  • Regulation Of Apoptotic Process
  • Innate Immune Response
  • Response To Axon Injury
  • Regulation Of Dendrite Morphogenesis
  • Regulation Of Neuron Death
  • Positive Regulation Of Neuron Death
Pathways
Drugs
Diseases
GWAS
  • Amyotrophic lateral sclerosis ( 27455348)
  • Amyotrophic lateral sclerosis (sporadic) ( 28931804)
  • Blood protein levels ( 29875488 28240269)
  • Osteoprotegerin levels ( 25080503)
Interacting Genes 6 interacting genes: CCDC47 IRAK2 MYD88 NLRX1 STT3A TICAM2
Entrez ID 23098
HPRD ID 09664
Ensembl ID ENSG00000004139
Uniprot IDs Q05B42 Q0D2N8 Q6SZW1
PDB IDs 6O0Q 6O0R 6O0S 6O0T 6O0U 6O0V 6O1B 6QWV 6WPK 7CM5 7CM6 7CM7
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025