AIF1

Description		allograft inflammatory factor 1
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GO Annotations	Cellular Component	Ruffle Phagocytic Cup Nucleus Cytoplasm Cytosol Actin Filament Lamellipodium Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Calcium Ion Binding Protein Binding Actin Filament Binding
	Biological Process	Microglial Cell Activation Phagocytosis, Engulfment Inflammatory Response Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Rac Protein Signal Transduction Actin Filament Polymerization Parallel Actin Filament Bundle Assembly Positive Regulation Of Cell Migration Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Cellular Response To Oxidative Stress Positive Regulation Of T Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Actin Filament Bundle Assembly Actin Crosslink Formation Cellular Response To Interferon-gamma Negative Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Fibroblast Growth Factor Production Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of T Cell Migration
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Crohn's disease ( 22936669) Heel bone mineral density ( 30598549) Height ( 23563607) Inflammatory bowel disease ( 28067908) Laryngeal squamous cell carcinoma ( 25194280) Malaria ( 31844061) Mean platelet volume ( 32888494) Neonatal lupus ( 20662065) Oral cavity cancer ( 27749845) Platelet count ( 32888494) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) Weight ( 19079260)
Interacting Genes		2 interacting genes: ACTA1 LCP1
Entrez ID		199
HPRD ID		03496
Ensembl ID		ENSG00000204472
Uniprot IDs		I3WTX1 P55008 Q4V347
PDB IDs		2D58 2G2B
Enriched GO Terms of Interacting Partners?
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