THEM4

Description		thioesterase superfamily member 4
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Plasma Membrane Ruffle Membrane
	Molecular Function	Protein Binding Palmitoyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		PIP3 activates AKT signaling Activation of AKT2 Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases
GWAS		Acylcarnitine levels ( 26068415) Asthma ( 31619474) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Eye movement (horizontal position gain) ( 30120336) Eye movement in schizophrenia (horizontal position gain) ( 30120336) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 24625756) Serum uric acid levels in response to allopurinol in gout ( 25676789) Urinary metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		1 interacting genes: AKT1
Entrez ID		117145
HPRD ID		16215
Ensembl ID		ENSG00000159445
Uniprot IDs		A8K0C9 Q5T1C6
PDB IDs		4AE8 4GAH
Enriched GO Terms of Interacting Partners?
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