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POLD3
Description
DNA polymerase delta 3, accessory subunit
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Zeta DNA Polymerase Complex
Delta DNA Polymerase Complex
Molecular Function
DNA-directed DNA Polymerase Activity
Protein Binding
Protein-macromolecule Adaptor Activity
Biological Process
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Strand Elongation Involved In DNA Replication
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
DNA Damage Response, Detection Of DNA Damage
DNA Biosynthetic Process
DNA Synthesis Involved In UV-damage Excision Repair
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Drugs
Diseases
GWAS
Colorectal cancer (
22634755
25990418
30529582
26151821
31826910
)
Colorectal cancer or advanced adenoma (
30510241
)
Diastolic blood pressure (
30224653
)
Hand grip strength (
29691431
29313844
)
Microalbuminuria (
26631737
)
Renal underexcretion gout (
32238385
)
Response to metformin (IC50) (
28173075
)
Interacting Genes
8 interacting genes:
APP
MBD3L2
PCNA
POLD1
POLD2
POLD4
REV1
SPRTN
Entrez ID
10714
HPRD ID
11446
Ensembl ID
ENSG00000077514
Uniprot IDs
A0A024R5M8
Q15054
PDB IDs
1U76
2N1G
3E0J
6S1M
6S1N
6S1O
6TNY
6TNZ
Enriched GO Terms of Interacting Partners
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