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NR1H3
Description
nuclear receptor subfamily 1 group H member 3
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Cholesterol Binding
Sterol Response Element Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Cholesterol Storage
Cell Differentiation
Intracellular Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Lipid Transport
Positive Regulation Of Cholesterol Transport
Response To Progesterone
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Phosphatidylcholine Acyl-chain Remodeling
Cholesterol Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Macrophage Activation
Apoptotic Cell Clearance
Positive Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Pinocytosis
Negative Regulation Of Inflammatory Response
Positive Regulation Of Lipoprotein Lipase Activity
Lipid Homeostasis
Sterol Homeostasis
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Triglyceride Homeostasis
Cellular Response To Lipopolysaccharide
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Secretion Of Lysosomal Enzymes
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways
PPARA activates gene expression
VLDLR internalisation and degradation
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs
TO-901317
N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diacerein
Rhein
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood glucose levels (
31928498
)
Creatinine levels (
29403010
)
Feeling miserable (
29500382
)
HDL cholesterol (
19060910
20686565
)
Hypertension (
31879980
)
Intraocular pressure (
29785010
)
Lymphocyte percentage of white cells (
27863252
)
Metabolic syndrome (
22399527
)
Monocyte percentage of white cells (
27863252
)
Mood instability (
31168069
)
Neurociticism (
29500382
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Triglyceride levels (
32154731
)
Triglycerides (
30275531
)
Interacting Genes
35 interacting genes:
ACTN1
APP
BAG3
CEP350
EDF1
FOXO3
GPANK1
ING3
KAT2B
KDM1A
LZTR1
MDFI
MSTO1
NCOA1
NCOA3
NCOA6
NCOR1
NR0B2
NR3C1
NRIP1
PPARA
PPARD
PPARG
PSMC5
RARA
RXRA
RXRB
RXRG
SIRT1
SS18L1
SUV39H1
SYT1
TMEM161A
UBE2I
ZXDC
Entrez ID
10062
HPRD ID
07211
Ensembl ID
ENSG00000025434
Uniprot IDs
B4DXU5
B5MBY7
F1D8N1
Q13133
PDB IDs
1UHL
3IPQ
3IPS
3IPU
5AVI
5AVL
5HJS
Enriched GO Terms of Interacting Partners
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