MICA

Description		MHC class I polypeptide-related sequence A
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding Beta-2-microglobulin Binding Natural Killer Cell Lectin-like Receptor Binding
	Biological Process	T Cell Mediated Cytotoxicity Immune Response To Tumor Cell Immune Response Cellular Response To DNA Damage Stimulus Response To Heat Viral Process Cytolysis Negative Regulation Of Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Gamma-delta T Cell Activation Regulation Of Immune Response Defense Response To Virus
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 23817571) Asthma ( 27182965 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 31619474 29273806) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basophil percentage of white cells ( 27863252) Behcet's disease ( 23001997) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 30072576 29875488 28240269) Cervical cancer ( 23482656) Chronic obstructive pulmonary disease ( 30804561) Clozapine-induced agranulocytosis ( 25187353) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cold sores ( 28928442) Cutaneous lupus erythematosus ( 25827949) Eosinophil counts ( 29403010) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Gastroesophageal reflux disease ( 31527586) Heel bone mineral density ( 30598549) Height ( 20881960) Hepatocellular carcinoma ( 21499248) Hip circumference adjusted for BMI ( 25673412) HIV-1 control ( 21051598) IgA levels ( 28628107) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Mononucleosis ( 28928442) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-chemotherapy drug induced agranulocytosis ( 27157822) Offspring birth weight ( 31043758) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Perceived unattractiveness to mosquitoes ( 28199695) Platelet distribution width ( 27863252) Pneumonia ( 28928442) Psoriasis ( 23143594) Pubertal anthropometrics ( 23449627) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rosacea symptom severity ( 29771307) Self-reported allergy ( 23817569) Takayasu arteritis ( 25604533 23830517) Tonsillectomy ( 27182965) Trichloroethylene-induced hypersensitivity syndrome ( 26190474) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Weight ( 28552196)
Interacting Genes		1 interacting genes: POT1
Entrez ID		100507436
HPRD ID
Ensembl ID		ENSG00000204520
Uniprot IDs		A0A024RCL3 A0A0G2JJ55 Q29983 Q96QC4
PDB IDs		1B3J 1HYR 6DDM 6DDR 6DDV
Enriched GO Terms of Interacting Partners?
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